Kinetic Modeling of Fermentative Production of 1, 3-Propanediol by Klebsiella pneumoniae HR526 with Consideration of Multiple Product Inhibitions |
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Authors: | Lu He Xuebing Zhao Keke Cheng Yan Sun Dehua Liu |
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Institution: | 1. Institute of Applied Chemistry, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China 2. Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, 100084, China
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Abstract: | During the fermentative production of 1, 3-propanediol (1,3-PD), the multiple product inhibitions cannot be negligible to accurately describe the kinetics of fermentation process. A kinetic model for fermentative production of 1,3-PD by Klebsiella pneumoniae HR526 with glycerol as carbon source under aerobic condition was proposed. The inhibitions of multiple products including 1,3-PD, 2, 3-butanediol (2,3-BD), acetate, and succinate were considered in the model. It was found that 1,3-PD, 2,3-BD, and acetate showed strong inhibitions to cell growth depending on their concentrations. The kinetic model was relatively accurate to predict the experimental data of batch, fed-batch, and continuous fermentations. The model thus can serve as a tool for further controlling and optimizing the fermentation process. |
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