Novel route to N-alkyl- and N,N"-dialkylhydrazines by high-pressure alkylation of azines |
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Authors: | N. E. Agafonov A. V. Dudin A. A. Preobrazhenskii |
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Affiliation: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
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Abstract: | Reactions of alkyl halides with azines of p-nitrobenzaldehyde, benzaldehyde, and p-methoxybenzaldehyde at a high pressure (10 kbar) were studied. Hydrolysis of the reaction mixtures gives pure N-monoalkyl- or N,N"-dialkylhydrazines in high yields, depending on the structure of the starting azine and the solvent nature. It was found that non-symmetrical N,N"-dialkylhydrazines can be synthesized without isolating intermediate N-monoquaternary immonium salts. The effect of the phase transition of the solvent on the direction of the alkylation is discussed. |
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Keywords: | azines hydrazines high-pressure alkylation |
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