Palladium-catalyzed cyanation of propargylic carbonates with trimethylsilyl cyanide |
| |
Authors: | Tsuji Taniguchi Yasuda Kawamura Obora |
| |
Affiliation: | Catalysis Research Center and Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan. tsuji@cat.hokudai.ac.jp |
| |
Abstract: | [reaction: see text]An equimolar mixture of propargylic carbonate (1) and trimethylsilyl cyanide (2) in THF under reflux affords cyanoallene (3) in the presence of a catalytic amount (5 mol %) of Pd(PPh3)4. In the reaction, the trimethylsilyl moiety of 2 effectively traps the leaving group of 1. The use of 2 in excess (6 equiv) provides dicyanated products (7 or 8) in high yields. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|