|
|||||
|
|
| 胆汁酸衍生物三羰基铼核配合物的合成与表征 | |
| 引用本文： | 黄立梁,朱华,刘贵锋,许嘉,沈玉梅.胆汁酸衍生物三羰基铼核配合物的合成与表征[J].有机化学,2009,12(3):396-402. |
| 作者姓名： | 黄立梁 朱华 刘贵锋 许嘉 沈玉梅 |
| 作者单位： | 1. 中国科学院上海应用物理研究所,放射性药物研究中心,上海201800;中国科学院研究生院,北京,100049 2. 中国科学院上海应用物理研究所,放射性药物研究中心,上海201800 |
| 基金项目： | 中国科学院"百人计划"项目，中国科学院前沿领域项目 |
| 摘 要： | 以胆酸、鹅去氧胆酸为起始原料, 经羧基的酯化、酯的胺解以及氨基的烷基化, 合成了一系列潜在的针对肝胆显像和肠显像的SPECT (Single photon emission computed tomography)分子探针前体. 该方法简便易行, 合成路线短, 产率高, 它们的结构已经过IR, 1H NMR, 13C NMR, HRMS和元素分析得到了证实. 这些结果为基于以胆汁酸为原料的放射性药物的研究奠定了基础. |
| 关 键 词： | 胆酸 鹅去氧胆酸 三齿吡啶配体 三羰基铼 |
| 收稿时间： | 2008-7-17 |
| 修稿时间： | 2008-9-16 |
Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives |
|
| HUANG Li-liang,ZHU Hua,LIU Gui-feng,XU Jia,SHEN Yu-mei.Synthesis and Characterization of Rhenium Tricarbonyl Core Complexes of Bile Acid Derivatives[J].Chinese Journal of Organic Chemistry,2009,12(3):396-402. | |
| Authors: | HUANG Li-liang ZHU Hua LIU Gui-feng XU Jia SHEN Yu-mei |
| Institution: | (a Research Center of Radiopharmaceuticals, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800) (b Graduate School of the Chinese Academy of Sciences, Beijing 100049) |
| Abstract: | A series of novel bile acid derivatives as potential hepato-biliary and intestinal scintigraphy imaging SPECT (single photon emission computed tomography) tracers were prepared from bile acids by es-terification, aminolysis of esters and alkylation of amino groups. The procedure is simple and easy to be car-ried out with high yields. Their structures have been confirmed by IR, 1H NMR, 13C NMR, HRMS tech-niques and elemental analysis. These results provide some opportunities for further research on radiophar-maceuticals based on bile acids. |
| Keywords: | bile acid chenodeoxycholic acid tridentate pyridine ligand rhenium tricarbonyl |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《有机化学》浏览原始摘要信息 | |
| 点击此处可从《有机化学》下载免费的PDF全文 | |