Chemiluminescence determination of melatonin and some of its derivatives using potassium permanganate and formaldehyde system |
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| Authors: | Email author" target="_blank">Guo?Nan?ChenEmail author Fu?Xin?Huang Xiao?Ping?Wu Zheng?Feng?Zhao Jian?Ping?Duan |
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| Institution: | (1) Department of Chemistry, Fuzhou University, 350002 Fuzhou, Fujian, China;(2) School of Engineering and Science, Monash University Malaysia, Bandar Sunway, 46150 Petaling Java, Selangor, Malaysia;(3) Analytical and Testing Center, Fuzhou University, 350002 Fuzhou, Fujian , China |
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| Abstract: | It was found that melatonin and its derivatives, such as N-acetyl- 5-methoxytryptamine (MT), N-acetyl-5-hydroxytryptamine (NAS), 5-Methoxytrypt- amine (5-MT), 5-Methoxyindolyl acetic acid (5-MIAA) and N-acetyl-5-methoxy- 6-hydroxytryptamine (6-HMT) would give chemiluminescence in the acidic potassium permanganate solution, and formaldehyde would enhance this chemiluminescent reaction greatly. The optimum conditions for this chemiluminescent reaction were studied in detail by a flow injection system. A new simple rapid method has been developed under the optimum conditions for determination of melatonin. This method has the advantages of high sensitivity, wide range of linear response and low detection limit. On the basis of investigation of chemiluminescent, fluorescent and UV spectra of melatonin in acidic solution containing potassium permanganate and formaldehyde, a possible mechanism of this reaction was proposed. |
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| Keywords: | Melatonin and its derivatives Chmeiluminescence Flow injection |
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