Palladium-catalyzed diastereoselective hydrogenation of N-substituted 3-methyleneisoindolin-1-ones |
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Authors: | Zh R Sagirova E V Starodubtseva O V Turova M G Vinogradov |
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Institution: | 1154. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
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Abstract: | An asymmetric synthesis of chiral N-substituted 3-methylisoindolin-1-ones was performed using the Pd0-catalyzed diastereoselective hydrogenation of their 3-methylene-substituted precursors, that has not been investigated earlier. The highest diastereoselectivity (67% de) was achieved when the hydrogenation was carried out in methanol mediated by a palladium catalyst (Pd/C) modified with cinchonidine. |
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