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Restructuring of the bleomycin metal core. Novel oxygen-activating ligands with symmetrized structure |
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| Authors: | Masami Otsuka Honoo Satake Yukio Sugiura Satoru Murakami Masakatsu ShibasakiSusumu Kobayashi |
| Affiliation: | Institute for Chemical Research, Kyoto University, Uji, Kyoto 611, Japan Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo113, Japan Sagami Chemical Research Center, Nishi-ohnuma, Sagamihara-shi, Kanagawa 229, Japan |
| Abstract: | Novel ligands having symmetrized coordination environment consisting of two histidine units and a pyridine are prepared. Oxygen activating efficiency of the iron complexes of the synthetic ligands increases by introducing electron donating substituent into the pyridine ring. |
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