Synthesis of symmetric macrocyclic diesterdihyrazides using successive [2+1]- and [1+1]-condensations |
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| Authors: | G. Yu. Ishmuratov G. R. Mingaleeva M. P. Yakovleva R. R. Muslukhov E. M. Vyrypaev S. P. Ivanov A. G. Tolstikov |
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| Affiliation: | (1) Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 450054 Ufa, Russia |
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| Abstract: | Potentially useful symmetric macrocyclic diesterdihydrazides were synthesized efficiently from available petrochemical products (tetrahydropyran and 4-methyltetrahydropyran) using successive [2+1]-condensation of 8-hydroxyoctan-2-one and its 6-methyl derivative with glutaric and adipic chlorides and [1+1]-condensation of the intermediate diketodiesters with glutaric dihydrazide. |
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