Synthesis,characterization and DNA binding studies of two cyclopentadienyl ruthenium(II) complexes with amino acid ligands |
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| Authors: | Xiu Lian Lu Lin Zhang Ji-Dong Lou Juan Yan Ping-Sheng Nong Xiao-Hong Chen Juan-Juan Yang Min Gao |
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| Institution: | (1) College of Life Sciences, China Institute of Metrology, 310018 Hangzhou, Zhejiang, People’s Republic of China;(2) State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, 100029 Beijing, People’s Republic of China |
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| Abstract: | Two new half-sandwich cyclopentadienyl ruthenium(II) complexes containing α-amino acids, CpRu(PPh3)2(Ser)] (Ser = l-serine) and CpRu(PPh3)(Met)] (Met = l-methionine), were synthesized and characterized by physicochemical methods. Interactions of these two complexes with calf
thymus DNA were investigated by UV–Vis absorption spectroscopy, emission spectroscopy and competitive binding studies. The
results indicate that both complexes can interact with DNA, leading to the damage of the double helix. CpRu(PPh3)2(Ser)] binds to DNA by intercalation, while the binding mode for CpRu(PPh3)(Met)] is more complicated due to the formation of an EB-DNA-complex (EB = ethidium bromide). The affinity of the Met complex
for DNA is stronger than that of the Ser complex, which could be due to groove–surface combination or electrostatic interaction
in addition to intercalative binding. |
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