Quantitative determination of acetylsalicylic acid in commercial drugs using DSC |
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| Authors: | Luigi Campanella Valentina Micieli Mauro Tomassetti Stefano Vecchio |
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| Institution: | (1) Department of Chemistry, Sapienza University of Rome, P.le A. Moro, 5, 00185 Rome, Italy;(2) Department of Chemical Engineering Materials and Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy; |
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| Abstract: | In this article, the quantitative determination of acetylsalicylic acid (ASA) contained in two of the most commercially available
pharmaceutical formulations was performed using differential scanning calorimetry (DSC) after a thermoanalytical characterization
and a preliminary test on compatibility of ASA with three of the most commonly considered excipients cellulose (CE), starch
(ST) and sodium saccharin (SS)]. Finally, the analytical results obtained were compared with those derived by titrimetry and
two UV spectrophotometric methods: i.e. a ‘direct method’ and a method based on first-order derivative UV spectra. |
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