Preparation and characterization of L-Leucine-modified amphiprotic bifunctional mesoporous SBA-15 molecular sieve as a drug carrier for ribavirin |
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Authors: | Zhigang Xu Min Guan Chuande Zhao |
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Institution: | a State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, 100191, PR China |
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Abstract: | In this study, an amphiphilic bifunctional mesoporous SBA-15 material (AMPBIF-SBA-15) was synthesized through post-synthesis method as a drug carrier. Ribavirin was selected as the model drug and whose release from both unmodified and functionalized SBA-15 was evaluated in four media solutions with different pH or ionic strength. The release process indicated that AMPBIF-SBA-15 was a pH-sensitive drug carrier, which showed a phased low-release effect to ribavirin in the simulated body fluid (PBS, pH 7.4) solution. The materials were further characterized by Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen adsorption-desorption measurements and elemental analysis. This study provided a novel drug carrier for ribavirin to improve curative effect of ribavirin. |
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Keywords: | Mesoporous SBA-15 silica molecular sieves Amphiprotic groups Drug carrier Controlled release Ribavirin |
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