Arylpiperazine derivatives of diphenylsulfide:Synthesis and evaluation for dual 5-HT1A/SSRI activities |
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| Authors: | Xue Dan Wu Dong Zhi Liu Ai Jun Li Xue Qin Zhou |
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| Institution: | a School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;b College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China |
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| Abstract: | The design, synthesis and biological evaluation of a novel series of arylpiperazine derivatives of diphenylsulfide with dual 5-HT1A/SSRI activities are reported. The target compounds exhibit low to moderate 5-HT transporter affinity and moderate to high 5-HT1A affinity. Compound 13a shows moderate dual activities and is a promising lead compound for further structure-activity relationships studies. |
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| Keywords: | Antidepressants 5-HT1A/SSRI Arylpiperazines 5-HT1A receptor Diphenylsulfide |
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