Distribution of 131I-labeled recombinant human erythropoietin in maternal and fetal organs following intravenous administration in pregnant rats |
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| Authors: | O Yilmaz F Y Lambrecht N Gokmen S Erbayraktar and K Durkan |
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| Institution: | (1) Department of Animal Research Center, Dokuz Eylul University School of Medicine, Izmir, Turkey;(2) Department of Nuclear Applications, Ege University Institute of Nuclear Sciences, Izmir, Turkey;(3) Department of Anesthesiology and Reanimation, Dokuz Eylul University School of Medicine, Izmir, Turkey;(4) Department of Neurosurgery, Dokuz Eylul University School of Medicine, Izmir, Turkey |
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| Abstract: | The aim of the present study was to demonstrate the possible transplacental transmission of 131I labeled recombinant human erythropoietin (131I-rh-EPO) in pregnant rats and its distribution through maternal and fetal organs. Six Wistar Albino Rats in their pregnancy
of 18 days were used 131I labeled recombinant human erythropoietin (specific activity = 2.4 μCi/IU) was injected into the tail vein of rats. After
30 minutes labeled erythropoietin infusion maternal stomach, kidney, lung, liver, brain and heart as well as fetus were removed.
Then, the same organs were removed from each fetus. Measuring weight of maternal and fetal organs as well as placenta were
followed by radioactivity count via Cd(Te) detector. 131I labeled recombinant human erythropoietin was found to be able to pass rat placenta and its distribution order in fetal organs
was similar to those of maternal organs. Besides, as measurements were performed closer to cornu uteri, uptakes were decreasing
in every fetus and its corresponding placenta. |
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