On MRI turbulence quantification |
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Authors: | Petter Dyverfeldt Roland Grdhagen Andreas Sigfridsson Matts Karlsson Tino Ebbers |
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Institution: | Petter Dyverfeldt, Roland Gårdhagen, Andreas Sigfridsson, Matts Karlsson,Tino Ebbers, |
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Abstract: | Turbulent flow, characterized by velocity fluctuations, accompanies many forms of cardiovascular disease and may contribute to their progression and hemodynamic consequences. Several studies have investigated the effects of turbulence on the magnetic resonance imaging (MRI) signal. Quantitative MRI turbulence measurements have recently been shown to have great potential for application both in human cardiovascular flow and in engineering flow. In this article, potential pitfalls and sources of error in MRI turbulence measurements are theoretically and numerically investigated. Data acquisition strategies suitable for turbulence quantification are outlined. The results show that the sensitivity of MRI turbulence measurements to intravoxel mean velocity variations is negligible, but that noise may degrade the estimates if the turbulence encoding parameter is set improperly. Different approaches for utilizing a given amount of scan time were shown to influence the dynamic range and the uncertainty in the turbulence estimates due to noise. The findings reported in this work may be valuable for both in vitro and in vivo studies employing MRI methods for turbulence quantification. |
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Keywords: | Turbulence quantification Turbulent flow Phase-contrast magnetic resonance imaging Constriction Numerical flow phantom |
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