Mild decarboxylative activation of malonic acid derivatives by 1,1'-carbonyldiimidazole |
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| Authors: | Lafrance Danny Bowles Paul Leeman Kyle Rafka Robert |
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| Affiliation: | Development Science and Technology, Pfizer Inc., Eastern Point Road, Groton, Connecticut 06340, United States. |
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| Abstract: | Malonic acid derivatives undergo unusually mild decarboxylation when treated with N,N'-carbonyldiimidazole (CDI) at room temperature to generate the carbonyl imidazole moiety in high yield, which can be reacted further with a variety of nucleophiles in an efficient one-pot process. |
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