Palladium catalyzed alkoxy- and aminocarbonylation of vinyl tosylates |
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| Authors: | Reeves Diana C Rodriguez Sonia Lee Heewon Haddad Nizar Krishnamurthy Dhileepkumar Senanayake Chris H |
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| Institution: | Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road/P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States. |
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| Abstract: | The palladium catalyzed alkoxycarbonylation and aminocarbonylation of vinyl tosylates are described. A variety of ketone and aldehyde derived vinyl tosylates may be carbonylated in the presence of primary, secondary, and tertiary alcohols, or primary and secondary amines, to provide the corresponding esters and amides in good yields. The alkoxycarbonylation was applied to a short synthesis of isoguvacine. |
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