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Enantioselective synthesis of the 4-hydroxy buteneolide terminus of mucocin and related annonaceous acetogenins |
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| Authors: | PAndrew Evans VSrinivasa Murthy |
| Institution: | Brown Laboratory, Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA |
| Abstract: | The 4-hydroxy buteneolide terminus 3, applicable to mucocin 1 and related annonaceous acetogenins, was prepared in an expeditious manner from the selenocarbonate 2 via an intramolecular acyl radical cyclization followed by an enantioselective Lewis-acid catalyzed Keck-allylation reaction. |
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