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Modelling of Amperometric Biosensors with Rough Surface of the Enzyme Membrane |
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| Authors: | R Baronas F Ivanauskas J Kulys M Sapagovas |
| Institution: | 1. Faculty of Mathematics and Informatics, Vilnius University, Naugarduko 24, 2600, Vilnius, Lithuania 2. Institute of Biochemistry, Mokslininku 12, 2600, Vilnius, Lithuania 3. Institute of Mathematics and Informatics, Akademijos 4, 2600, Vilnius, Lithuania |
| Abstract: | A two-dimensional-in-space mathematical model of amperometric biosensors has been developed. The model is based on the diffusion equations containing a nonlinear term related to the Michaelis–Menten kinetic of the enzymatic reaction. The model takes into consideration two types of roughness of the upper surface (bulk solution/membrane interface) of the enzyme membrane, immobilised onto an electrode. Using digital simulation, the influence of the geometry of the roughness on the biosensor response was investigated. Digital simulation was carried out using the finite-difference technique. |
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