N-heterocyclic carbene-catalyzed nucleophilic aroylation of fluorobenzenes |
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Authors: | Suzuki Yumiko Ota Shinya Fukuta Yoshinori Ueda Yuki Sato Masayuki |
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Institution: | School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. suzuyumi@u-shizuoka-ken.ac.jp |
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Abstract: | In N-heterocyclic carbene (NHCs) catalyzed nucleophilic substitution of fluorobenzenes, fluoro groups are replaced by aroyl groups, which are derived from aromatic aldehydes. 1,3,4,5-Tetramethylimidazol-2-ylidene is found to be an efficient catalyst. The catalyst loading can be reduced to 1 mol % without a significant decrease in the product yields. Polysubstituted benzophenones are synthesized from fluorobenzenes and benzaldehydes by the NHC-catalyzed aroylation. |
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