New antifungal 1,2,4-triazoles with difluoro(substituted sulfonyl)methyl moiety |
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| Authors: | Eto H Kaneko Y Takeda S Tokizawa M Sato S Yoshida K Namiki S Ogawa M Maebashi K Ishida K Matsumoto M Asaoka T |
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| Institution: | Central Research Labs., SS Pharmaceutical Co., Ltd., Narita, Chiba, Japan. Hiromichi.Eto@ssp.co.jp |
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| Abstract: | New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d showed potent antifungal activities. |
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