Synthesis of benzonorcaradienes by gold(I)-catalyzed [4+3] annulation |
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| Authors: | Gorin David J Dubé Pascal Toste F Dean |
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| Institution: | Department of Chemistry, University of California, Berkeley, California 94720, USA. |
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| Abstract: | A formal 4 + 3]-annulation of vinyl arenes and diynyl propargyl esters is described. A mechanism involving cationic phosphinegold(I)-catalyzed tandem cyclopropanation/hydroarylation to produce the benzonorcaradiene products is proposed. In accord with this mechanism, the alkynyl cyclopropane can also be prepared with excellent regio- and diastereocontrol. |
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