Paroxysmal starting and stopping of circulating waves in excitable media |
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Authors: | Nagai Y González H Shrier A Glass L |
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Affiliation: | Centre for Nonlinear Dynamics in Physiology and Medicine, 3655 Drummond Street, Montreal, Quebec, H3G 1Y6 Canada. |
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Abstract: | Levels of intracellular Ca2+ were monitored using fluorescence from Ca2+-sensitive dyes in chick embryonic heart cells cultured in an annular geometry. There was spontaneous starting and stopping of reentrant waves of activity. The results are modeled using modified FitzHugh-Nagumo equations representing pacemakers embedded in a conducting medium. These results provide a potential mechanism for spontaneous abnormal cardiac rhythms in which there are rapid heart beats (tachycardias) that repetitively start and stop. |
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