Microwave promoted synthesis of cycl[3.2.2]azines in water via a new three-component reaction |
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| Authors: | Shyamalee GogoiMandakini Dutta Junali GogoiRomesh Chandra Boruah |
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| Affiliation: | Medicinal Chemistry Division, North East Institute of Science & Technology (CSIR), Jorhat 785 006, India |
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| Abstract: | A microwave-promoted and base-catalyzed synthesis of cycl[3.2.2]azines is accomplished in water via a three-component reaction (3-CR) of 2-picoline, α-bromoacetophenone and alkyne. The extension of the methodology to the synthesis of steroidal and carbocyclic cycl[3.2.2]azine is also reported. |
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