Polymorphism and Cyclodextrin Inclusion of Salbutamol Laurate |
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Authors: | Caira M R Dodds D R Nassimbeni L R |
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Institution: | (1) Department of Chemistry, University of Cape Town, Rondebosch, 7701, South Africa |
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Abstract: | Salbutamol laurate is a novel salt form of the well-known bronchodilator salbutamol (albuterol). Its polymorphism and inclusion
in (2-hydroxypropyl)-β-cyclodextrinwere investigated by thermogravimetry, differential scanning calorimetry, infrared and
powder X-ray diffraction techniques. Two polymorphic forms of the salt were identified. Conditions for inclusion complex formation
between the salt and (2-hydroxypropyl)-β-cyclodextrin, namely prolonged co-grinding and kneading, were established by a combination
of the above methods.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | cyclodextrincomplex polymorphs salbutamol laurate |
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