Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst |
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| Authors: | Miura Tsuyoshi Kasuga Hikaru Imai Kie Ina Mariko Tada Norihiro Imai Nobuyuki Itoh Akichika |
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| Institution: | Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan. miura@gifu-pu.ac.jp |
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| Abstract: | A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification. |
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