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Studies on lysergic acid diethylamide and related compounds—VI: Steric requirements of von braun reaction
Authors:Y Nakahara  T Niwaguchi  H Ishii
Institution:National Research Institute of Police Science, Chiyoda-ku, Tokyo, Japan;Faculty of Pharmaceutical Sciences, Chiba University, 1-33, Yayoi-cho, Chiba, Japan
Abstract:It has been shown that in the ergot alkaloid series the von Braun reaction is hindered if there is a substituent which is 1,3-diaxial with respect to the nitrogen lone pair in the prefered conformation.
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