Asymmetric multicomponent [C+NC+CC] synthesis of highly functionalized pyrrolidines catalyzed by silver(I) |
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| Authors: | Garner Philip Kaniskan H Umit Hu Jieyu Youngs Wiley J Panzner Matthew |
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| Institution: | Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA. ppg@case.edu |
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| Abstract: | reaction: see text] Highly functionalized pyrrolidines are obtained in a single chemical step via a mild, efficient, and selective Ag(I)-catalyzed asymmetric C+NC+CC] coupling process. Oppolzer's camphorsultam enables the desired reaction cascade and provides a reliable means to control the developing stereochemistry and purify the products. This three-component reaction provides unprecedented access to structurally diverse pyrrolidines for both target- and diversity-oriented syntheses. |
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