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The impact of a carbon nanotube on the cholesterol domain localized on a protein surface
Authors:Zygmunt Gburski  Krzysztof Górny  Przemys?aw Raczyński
Institution:1. College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, PR China;2. Korean Bioinformation Center (KOBIC), Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea;3. Department of Bioinformatics, University of Sciences and Technology, Daejeon 305-350, Republic of Korea;4. Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 135-710, Republic of Korea;5. Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, PR China;2. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland;3. John Curtin School of Medical Research, Australian National University, Canberra, Australia;1. National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, Anhui, PR China;2. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, PR China;3. Division of Nanomaterials & Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, Hefei 230026, Anhui, PR China;1. Surface Physics and Material Science Division, Saha Institute of Nuclear Physics, 1/AF Bidhannagar City, Kolkata 700064, India;2. Computational Sciences Division, Saha Institute of Nuclear Physics, Kolkata 700064, India
Abstract:The influence of a single walled carbon nanotube on the structure of a cholesterol cluster (domain) developed over the surface of the endothelial protein 1LQV has been investigated using the classical molecular dynamics (MD) simulation technique. We have observed a substantial impact of carbon nanotube on the arrangement of the cholesterol domain. The carbon nanotube can drag out cholesterol molecules, remarkably reducing the volume of the domain that settles down on the protein.
Keywords:
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