Isolation and structure of koshikalide,a 14-membered macrolide from the marine cyanobacterium Lyngbya sp. |
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| Authors: | Arihiro Iwasaki Toshiaki Teruya Kiyotake Suenaga |
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| Institution: | Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | A 14-membered macrolide, koshikalide (1), was isolated from the marine cyanobacterium Lyngbya sp., and its planar structure was elucidated by spectroscopic analysis. The relative stereochemistry of C-11 and C-13 was elucidated by NOESY experiments and by an analysis of 1H–1H coupling constants. Koshikalide (1) exhibited weak cytotoxicity against HeLa S3 cells. |
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