Enantioselective total synthesis of idesolide via NaHCO3-promoted dimerization |
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| Authors: | Tomohiro Nagasawa Naoyuki Shimada Munefumi Torihata Shigefumi Kuwahara |
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| Affiliation: | Laboratory of Applied Bioorganic Chemistry, Graduate School of Agricultural Science, Tohoku University, Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan |
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| Abstract: | The enantioselective total synthesis of idesolide has been accomplished in 20% overall yield from a known allylic alcohol by a nine-step sequence involving the Sharpless asymmetric epoxidation as the source of chirality and an efficient NaHCO3-promoted dimerization of the monomeric form of idesolide as the key transformation. |
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