Enantioselective Palladium‐Catalyzed Oxidative β,β‐Fluoroarylation of α,β‐Unsaturated Carbonyl Derivatives |
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| Authors: | Javier Miró Dr Carlos del?Pozo Prof F Dean Toste Prof Santos Fustero |
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| Institution: | 1. Departamento de Química Orgánica, Universidad de Valencia, Burjassot, Spain;2. Department of Chemistry, University of California, Berkeley, CA, USA;3. Laboratorio de Moléculas Orgánicas, Centro de Investigación Príncipe Felipe, Valencia, Spain |
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| Abstract: | The site‐selective palladium‐catalyzed three‐component coupling of deactivated alkenes, arylboronic acids, and N‐fluorobenzenesulfonimide is disclosed herein. The developed methodology establishes a general, modular, and step‐economical approach to the stereoselective β‐fluorination of α,β‐unsaturated systems. |
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| Keywords: | alkenes fluorine palladium reaction mechanisms synthetic methods |
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