Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide |
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| Authors: | Jiansheng Zhu Yafei Liu Prof. Dr. Qilong Shen |
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| Affiliation: | Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China |
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| Abstract: | A general method for the formation of alkyl difluoromethylethers under mild reaction conditions and with good functional‐group tolerance was developed. The development of the method was based on the invention of a stable, electrophilic, difluoromethylating reagent, difluoromethyl‐(4‐nitrophenyl)‐bis(carbomethoxy) methylide sulfonium ylide, which was synthesized by reaction of the easily available 4‐nitrophenyl (difluoromethyl)thioether and dimethyl diazomalonate in the presence of a rhodium catalyst. |
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| Keywords: | alcohols fluorine reaction mechanisms synthetic methods ylides |
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