Total Synthesis of (+)‐Minfiensine: Construction of the Tetracyclic Core Structure by an Asymmetric Cascade Cyclization |
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Authors: | Ze‐Xin Zhang Si‐Cong Chen Prof. Dr. Lei Jiao |
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Affiliation: | Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing, China |
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Abstract: | A new method for one‐step construction of the tetracyclic core structure of the indole alkaloid (+)‐minfiensine was developed utilizing a palladium‐catalyzed asymmetric indole dearomatization/iminium cyclization cascade. An efficient total synthesis of (+)‐minfiensine was realized using this strategy. The present method enables access to the common core structure of a series of monoterpene indole alkaloids, such as vincorine, echitamine, and aspidosphylline A. |
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Keywords: | alkaloids cyclizations natural products palladium total synthesis |
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