Optimized free energies from bidirectional single-molecule force spectroscopy |
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Authors: | Minh David D L Adib Artur B |
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Affiliation: | Laboratory of Chemical Physics, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. daveminh@gmail.com |
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Abstract: | An optimized method for estimating path-ensemble averages using data from processes driven in opposite directions is presented. Based on this estimator, bidirectional expressions for reconstructing free energies and potentials of mean force from single-molecule force spectroscopy-valid for biasing potentials of arbitrary stiffness-are developed. Numerical simulations on a model potential indicate that these methods perform better than unidirectional strategies. |
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