| Abstract: | Quinazoline derivatives have received great interest because of their potential biological activity. This communication describes a facile method for the synthesis of substituted thiophenopyrimidones. 2-Amino-3-earbethoxy-4,5-tetramethylenethiophene on heating with substituted imidoyl-chlorides, iminoethers, iminothioethers or thioamides affords thiophenopyrimidones. By using this method a number of such compounds of varying complexity were synthesized which are otherwise not so easily accessible. |
