| Enzymatic Synthesis of Dipeptide Derivatives Containing Non-coded Amino Acids in Organic Solvents |
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| 作者姓名： | 杨洪 周闯 田桂玲 叶蕴华 |
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| 作者单位： | YANG，Hong ZHOU，Chuang TIAN，Gui-Ling YE，Yun-HuaKey Laboratory of Bio-organic Chemistry and Molecular Engineering of Education Ministry，College of Chemistry and Molecular Engineering，Peking University，Beijing 100871，China |
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| 基金项目： | theNationalNaturalScienceFoundationofChina (No.2 9872 0 0 2 ) |
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| 摘 要： | ＩｎｔｒｏｄｕｃｔｉｏｎＥｎｚｙｍａｔｉｃｐｅｐｔｉｄｅｓｙｎｔｈｅｓｉｓｈａｓｄｒａｗｎｍｕｃｈａｔｔｅｎ ｔｉｏｎｂｅｃａｕｓｅｏｆｉｔｓａｄｖａｎｔａｇｅｏｆｅｎｚｙｍｅｓｔｅｒｅｏｓｐｅｃｉｆｉｃｉｔｙ ,ｍｉｌｄｒｅａｃｔｉｏｎｃｏｎｄｉｔｉｏｎｓ ,ｍｉｎｉｍｕｍｓｉｄｅ ｃｈａｉｎｐｒｏｔｅｃｔｉｏｎａｎｄａｖｏｉｄａｎｃｅｏｆｒａｃｅｍｉｚａｔｉｏｎ .Ｂｕｔｔｈｅｓｔｒｉｃｔｓｕｂｓｔｒａｔｅｓｐｅｃｉｆｉｃｉｔｙｏｆｔｈｅｅｎｚｙｍｅｓｌｉｍｉｔｓｔｈｅｉｒａｐｐｌｉｃａｔｉｏｎｓ .…
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Enzymatic Synthesis of Dipeptide Derivatives Containing Non-coded Amino Acids in Organic Solvents |
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| YANG,Hong ZHOU,Chuang TIAN,Gui-Ling YE,Yun-HuaKey Laboratory of Bio-organic Chemistry and Molecular Engineering of Education Ministry,College of Chemistry and Molecular Engineering,Peking University,Beijing ,China.Enzymatic Synthesis of Dipeptide Derivatives Containing Non-coded Amino Acids in Organic Solvents[J].Chinese Journal of Chemistry,2002,20(11):1354-1357. |
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| Authors: | YANG Hong ZHOU Chuang TIAN Gui-Ling YE Yun-HuaKey Laboratory of Bio-organic Chemistry and Molecular Engineering of Education Ministry College of Chemistry and Molecular Engineering Peking University Beijing China |
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| Institution: | YANG,Hong ZHOU,Chuang TIAN,Gui-Ling YE,Yun-HuaKey Laboratory of Bio-organic Chemistry and Molecular Engineering of Education Ministry,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871,China |
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| Abstract: | A series of dipeptide derivatives containing non-coded amino acids, N-Boc-4-X-Phe-Ala-NHNHPh (X=Cl, Br, I, NO 2), were synthesized by using thermoase in organic solvents. The physical data were consistent with the same samples prepared by 3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT). Influence of different substituted groups of the non-coded amino acids and different organic solvents on the enzymatic peptide synthesis was studied. |
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| Keywords: | thermoase DEPBT non-coded amino acid enzymatic synthesis peptide |
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