| Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum |
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| 作者姓名： | JingLinKONG XiuBaoDU ChongXuFAN YingCAO HuiJIANG JianFuXU XiaoJunZHENG |
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| 作者单位： | ResearchInstituteofPharmaceuticalChemistry,Beijing102205 |
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| 摘 要： | A novel polypeptide was isolated from mistletoe Viscum coloratum. The primarystructure of the polypeptide ‘named viscotoxin B2‘ was determined to be KSCCKNTTGRNIYNT CRFAGGSRERCAKLSGCKIISASTCPSDYPK by Edman degradation. Viscotoxin B2 shared highsequence homology with viscotoxins isolated from Viscum album. Pharmacological experimentsshowed that viscotoxin B2 had distinct cytotoxic activity on tumor cells. Viscotoxin B2 could beused as a leading compound in cancer therapy.
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| 关 键 词： | 槲寄生 多肽 分离 净化 结构 槲寄生毒肽 |
Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum |
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| JingLinKONG XiuBaoDU ChongXuFAN YingCAO HuiJIANG JianFuXU XiaoJunZHENG.Purification and Primary Structure Determination of a Novel Polypeptide Isolated from Mistletoe Viscum coloratum[J].Chinese Chemical Letters,2004,15(11):1311-1314. |
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| Authors: | Jing Lin KONG Xiu Bao DU Chong Xu FAN Ying CAO Hui JIANG Jian Fu XU Xiao Jun ZHENG Research Institute of Pharmaceutical Chemistry Beijing |
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| Institution: | Jing Lin KONG*,Xiu Bao DU,Chong Xu FAN,Ying CAO Hui JIANG,Jian Fu XU,Xiao Jun ZHENG Research Institute of Pharmaceutical Chemistry,Beijing 102205 |
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| Abstract: | A novel polypeptide was isolated from mistletoe Viscum coloratum. The primary structure of the polypeptide named viscotoxin B2 was determined to be KSCCKNTTGRNIYNT CRFAGGSRERCAKLSGCKIISASTCPSDYPK by Edman degradation. Viscotoxin B2 shared high sequence homology with viscotoxins isolated from Viscum album. Pharmacological experiments showed that viscotoxin B2 had distinct cytotoxic activity on tumor cells. Viscotoxin B2 could be used as a leading compound in cancer therapy. |
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| Keywords: | Viscum coloratum isolation primary structure viscotoxin |
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