| 末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究 |
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| 引用本文： | 张世平,朱霞霞,宫永宽.末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究[J].化学学报,2009,67(16):1903-1909. |
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| 作者姓名： | 张世平 朱霞霞 宫永宽 |
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| 作者单位： | (西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室 西安 710069) |
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| 基金项目： | 国家自然科学基金(No20774073);;陕西省教育厅专项科研计划(No07JK416)资助项目 |
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| 摘 要： | 采用四步反应合成了一种新的具有良好生物相容性和生物降解性的末端带有磷酰胆碱(PC)基团的聚丁二酸丁二醇酯PBS-PC. 采用1H NMR、IR、凝胶色谱(GPC)和X射线光电子能谱(XPS)表征了聚合物的结构. 同时研究了聚合物的亲疏水性能、体外降解、溶胀率和对模型药物中性红的缓释性能. 结果显示: PC基团引入, 在一定程度上提高了PBS的亲水性、降解速率、溶胀率和对中性红的缓释性能.
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| 关 键 词： | 聚丁二酸丁二醇酯 磷酰胆碱 体外降解 溶胀 中性红 药物控释 |
| 收稿时间： | 2009-1-11 |
| 修稿时间： | 2009-3-16 |
Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate) |
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| Zhang Shiping,Zhu Xiaxia,Gong Yongkuan.Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate)[J].Acta Chimica Sinica,2009,67(16):1903-1909. |
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| Authors: | Zhang Shiping Zhu Xiaxia Gong Yongkuan |
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| Institution: | (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry & Materials Science, Northwest University, Xi’an 710069) |
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| Abstract: | A new biodegradable and biocompatible polymer, phosphorylcholine functionalized poly(butylene succinate) (PBS-PC) was synthesized via a four-step synthetic strategy. The results of 1H NMR, IR, gel permeation chromatography (GPC) and X-ray photoelectron spectroscopy (XPS) measure- ments demonstrated a successful construction of PBS-PC. Dynamic contact angle, in vitro degradation, swelling behavior and drug release measurements revealed that the PBS-PC showed higher hydrophilicity, degradation, swelling and f... |
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| Keywords: | poly(butylene succinate) phosphorylcholine in vitro degradation swelling behavior neutral red drug release |
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