Selection of adequate optimization criteria in chromatographic separations |
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Authors: | P F Vanbel P J Schoenmakers |
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Institution: | (1) Polymer-Analysis Group, Van’t Hoff Institute for Molecular Sciences (HIMS), Faculty of Science, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands;(2) Humont 21, B-7901 Thieulain, Belgium |
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Abstract: | Computer-assisted optimization of chromatographic separations is still a fruitful activity. In fact, advances in computerized
data handling should make the application of systematic optimization strategies much easier. However, in most contemporary
applications, the optimization criterion is not considered to be a key issue (Vanbel, J Pharm Biomed, 21:603–610, 1999). In this paper, an update of the importance of selecting adequate criteria in chromatographic separation is presented. |
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Keywords: | Optimization criteria HPLC separation Two-dimensional chromatography Multicriteria decision techniques Chemometrics |
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