Palladium catalyzed C-N bond formation in the synthesis of 7-amino-substituted tetracyclines |
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Authors: | Koza Darrell J Nsiah Yaw A |
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Institution: | Eastern Connecticut State University, Center for Antimicrobial Resistance, Goddard Hall, 83 Windham Street, Willimantic, Connecticut 06226, USA. kozad@easternct.edu |
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Abstract: | A facile synthesis of 7-alkylamino- and 7-cycloalkylaminotetracycline derivatives has been accomplished using an in situ generated aminostannane precursor. This procedure is advantageous in that it allows the concise synthesis of a number of unreported tetracycline derivatives that are cumbersome to prepare through traditional methods. These compounds are crucial to understanding structure activity relationships in the D-ring of tetracycline-type antibiotics and the acquired efflux resistance mechanism to this class of antibiotics. |
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