A cyclic RGD-coated peptide nanoribbon as a selective intracellular nanocarrier |
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Authors: | Lim Yong-Beom Kwon Oh-Joon Lee Eunji Kim Pyung-Hwan Yun Chae-Ok Lee Myongsoo |
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Affiliation: | Centre for Supramolecular Nano-Assembly, Department of Chemistry, Yonsei University, Shinchon 134, Seoul 120-749, Korea. |
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Abstract: | We have synthesized a peptide-based supramolecular building block consisting of a cyclic Arg-Gly-Asp (cRGD) peptide segment and a beta-sheet-forming peptide segment. The block peptide was shown to self-assemble into a cRGD-coated nanoribbon structure, as revealed by circular dichroism (CD), dynamic light scattering (DLS), and transmission electron microscopy (TEM) studies. We have shown that this cRGD-coated nanoribbon can encapsulate hydrophobic guest molecules and deliver them into cells. Colocalization of the nanoribbon with LysoTracker and the selective intracellular delivery results suggests that the cRGD-coated nanoribbon is likely to be internalized into the cells through integrin receptors. |
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