A photochemical route for efficient cyclopeptide formation with a minimum of protection and activation chemistry |
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Authors: | Griesbeck Axel G Heinrich Thomas Oelgemöller Michael Lex Johann Molis Arne |
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Affiliation: | Institute of Organic Chemistry, University of Cologne, Greinstrasse 4, D-50939 K?ln, Germany. griesbeck@unikoeln.de |
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Abstract: | An elaborated protocol is described which allows the efficient transformation of di-, tri-, and tetrapeptides into cyclopeptides with a minimum of protection and activation chemistry using the photoinduced electron transfer initiated decarboxylation of N-phthaloyl peptides resulting in C-C coupling between the initially formed carbon radicals. |
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