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Polypeptide grafted hyaluronan: A self-assembling comb-branched polymer constructed from biological components |
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| Authors: | Kandadai Madhuvanthi A Anumolu Rajasekhar Wang Xiaojun Baskaran Durairaj Pease Leonard F Bedrov Dmitry Smith Grant D Mays Jimmy W Magda Jules J |
| Institution: | aDepartment of Chemical Engineering, University of Utah, 50 S. Central Campus Drive, Rm. 3290, Salt Lake City, UT 84112, USA;bDepartment of Chemistry, University of Tennessee at Knoxville, 552 Buehler Hall, 1420 Circle Drive, Knoxville, TN 37996-1600, USA;cDepartment of Materials Science & Engineering, University of Utah, 120 S. Central Campus Drive, Salt Lake City, UT, USA |
| Abstract: | Rheological evidence is provided demonstrating that covalent grafting of monodisperse isotactic poly(l-leucine) branches onto linear hyaluronan (HA) polysaccharide chains yields comb-branched HA chains that self-assemble into long-lived physical networks in aqueous solutions driven by hydrophobic interactions between poly(l-leucine) chains. This is in stark contrast to native (unmodified) HA solutions which exhibit no tendency to form long-lived physical networks. |
| Keywords: | Hyaluronic acid Polypeptide Viscoelasticity Hydrophobic interaction |
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