Dynamic NMR investigation of two new interconvertible diasteriomeric epimers of natural 2-benzyl-2-hydroxybenzofuranone derivative from Pterocarpus marsupium |
| |
| Authors: | Rajesh K. Grover Raja Roy |
| |
| Affiliation: | a NMR Laboratory, Division of SAIF, Central Drug Research Institute, Lucknow 226001, India
b Division of Medicinal Chemistry, Central Drug Research Institute, Lucknow 226001, India |
| |
| Abstract: | The first example of a pair of interconvertible diastereomeric epimers 2α/2β-hydroxy-2-p-hydroxybenzyl-3(2H)-benzofuranone-7-C-β-d-glucopyranoside isolated from the heartwood of Pterocarpus marsupium is reported. The predominance of 1a over 1b was supported by dynamic exchange rates and activation parameters obtained from NMR studies. The mechanism of this unique phenomenon is thought to be operative by the formation of diketone as suggested by deuterium exchange. |
| |
| Keywords: | Dynamic NMR Deuterium NMR Mechanism and Pterocarpus marsupium |
| 本文献已被 ScienceDirect 等数据库收录！ |
