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Synthesis of the marine alkaloid caulersin |
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| Authors: | Niklas Wahlström Birgitta Stensland |
| Institution: | a Unit for Organic Chemistry, CNT, Department of Biosciences at Novum, Karolinska Institute, Novum Research Park, SE-141 57 Huddinge, Sweden b Södertörn University College, SE-141 04 Huddinge, Sweden c Preformulation and Biopharmaceutics, Solid State Analysis/SBBG B314:3, Astrazeneca PAR & D, SE-151 85 Södertälje, Sweden |
| Abstract: | A three-step synthesis of caulersin (3) from indole-2-acetic acid methyl ester and indole-2-carbonyl chloride is described. As the spectral data of the synthetic sample differed from those reported for the natural product, the structure was determined by X-ray crystallography. |
| Keywords: | Caulersin Marine alkaloid Vilsmeier salt Indole |
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