|
|||||
|
|
Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones |
|
| Authors: | Jé rô me Dauvergne,Vasudev Jadhav,Marie-Christine Matos,Michael R Pitts,Sanjay K Singh,John Whittall |
| Affiliation: | a Charterhouse Therapeutics Ltd, Robert Robinson Building, University of Liverpool, Liverpool L69 7ZD, UK b Stylacats Ltd, Development Labs, Cheshire Manufacturing Park, Ellesmere Port, Cheshire, UK c Stylacats Ltd, Research Labs, Robert Robinson Building, University of Liverpool, Liverpool L69 7ZD, UK |
| Abstract: | Three different methods are reported for the preparation of 4-azacyclo-2-enones 1, two of which allow the preparation of the compounds in optically active form. In addition, a facile route to 4-aza-5,5-dimethylcyclopent-2-enones 2 is disclosed. |
| Keywords: | 4-Aza-cyclopentenones 4-Aza-cyclopent-2-en-1-ols Asymmetric synthesis of aminocyclopentenols Lipase resolution |
| 本文献已被 ScienceDirect 等数据库收录！ | |