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Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones |
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| Authors: | Jérôme Dauvergne Vasudev Jadhav Marie-Christine Matos Michael R Pitts Sanjay K Singh John Whittall |
| Institution: | a Charterhouse Therapeutics Ltd, Robert Robinson Building, University of Liverpool, Liverpool L69 7ZD, UK b Stylacats Ltd, Development Labs, Cheshire Manufacturing Park, Ellesmere Port, Cheshire, UK c Stylacats Ltd, Research Labs, Robert Robinson Building, University of Liverpool, Liverpool L69 7ZD, UK |
| Abstract: | Three different methods are reported for the preparation of 4-azacyclo-2-enones 1, two of which allow the preparation of the compounds in optically active form. In addition, a facile route to 4-aza-5,5-dimethylcyclopent-2-enones 2 is disclosed. |
| Keywords: | 4-Aza-cyclopentenones 4-Aza-cyclopent-2-en-1-ols Asymmetric synthesis of aminocyclopentenols Lipase resolution |
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