Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera |
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Authors: | Vichai Reutrakul Chongkon Krachangchaeng Manat Pohmakotr Chalobon Yoosook Samaisukh Sophasan Thawatchai Santisuk |
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Institution: | a Department of Chemistry, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand b Department of Radiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand c Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand d Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand e The Forest Herbarium, Department of Royal Forest, Phaholyothin Road, Bangkok 10900, Thailand |
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Abstract: | Two new natural cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known coronalolide (3) and coronalolide methyl ester (4) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3′,5′-trihydroxy-7,4′-dimethoxyflavone (5), five known flavones 6-10 and hexacosyl 4′-hydroxy-trans-cinnamate (11) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods. Compounds 3, 7, 9, and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5-10 were also found to be active in the ΔTat/RevMC 99 syncytium assay. |
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Keywords: | Ring-A seco-cycloartane Octanolide Flavones Cytotoxic activity Anti-HIV activity |
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