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New developments in zinc-catalyzed asymmetric hydrosilylation of ketones with PMHS |
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| Authors: | Virginie Bette Diego Savoia |
| Institution: | a Chimie Organique Appliquée, UPRESA 8010 CNRS-Université de Lille 1, ENSCL, BP 108, 59652 Villeneuve d'Ascq Cedex, France b Dipartimento di Chimica ‘G. Ciamician’, Università di Bologna, via Selmi 2, 40126 Bologna, Italy c Organométalliques et Catalyse, UMR 6509 CNRS-Université de Rennes 1, Institut de Chimie, Campus de Beaulieu, 35042 Rennes Cedex, France |
| Abstract: | The influence of structural modifications of the diamine ligand and the ZnR2 precursor in the ZnR2-diamine]-catalyzed asymmetric hydrosilylation of prochiral ketones with PMHS in aprotic medium is reported. A new diamine ligand giving up to 91% ee in the reduction of acetophenone is described. The scope of this reduction system has been investigated using variously functionalized ketones and some deactivation pathways have been identified. |
| Keywords: | Asymmetric catalysis Diamines Hydrosilylation Ketones PMHS Zinc |
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