Polymer-supported thioanisole: a versatile platform for organic synthesis reagents |
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Authors: | Matthew Kwok Wai Choi |
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Affiliation: | Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China |
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Abstract: | A new cross-linked polystyrene-supported thioanisole reagent is reported. This reagent incorporates the flexible JandaJel™ cross-linker and can be treated with methyl trifluoromethanesulfonate to form the corresponding sulfonium salt. This salt can in turn be deprotonated to form a polymer-supported sulfur ylide that is able to react with aldehydes and ketones to form epoxides. The thioanisole reagent can also be oxidized to form an insoluble sulfoxide reagent that is useful in Swern oxidation reactions. In these reactions, the polymer-supported thioanisole-based reagents can be recovered, regenerated and reused. |
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Keywords: | Thioanisole JandaJel&trade Epoxide |
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