Further studies on palladium-catalyzed bismetallative cyclization of enynes in the presence of Bu3SnSiMe3 |
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Authors: | Yoshihiro Sato Miwako Mori |
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Institution: | Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo 060-0812, Japan |
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Abstract: | Bismetallative cyclization of enynes with Bu3SnSiMe3 catalyzed by Pd(0) complex was realized for the first time, which gives cyclized products containing a vinylsilane moiety and a homoallyltin moiety in good yield. In this cyclization, Pd2(dba)3·CHCl3 or Pd(OH)2 on charcoal is effective as a Pd(0) catalyst and the addition of a phosphine ligand increased the formation of alkyne bismetallation by-product. On the other hand, it was found that a nucleophilic N-heterocyclic carbene could be utilized as a ligand for this cyclization. The utility of the cyclized products obtained from this cyclization in synthetic organic chemistry have been proven by transformation into cyclopropanol derivatives. |
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Keywords: | Palladium Silylstannane Bismetallation Enyne Cyclization N-heterocyclic carbene |
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